• MOLFAC A.I. (MOLFAC AI or A.I. in general) uses custom, action specific computers to run models that learn from existing data of old molecules.
  • The current trained model includes hundreds of thousands of molecules and will grow as new molecules are generated and validated by MOLFAC A.I.
  • MOLFAC A.I. was used to discover that an old molecule with no addictive properties could be used for severe pain management (OpiX pain platform).
  • MOLFAC A.I. has also found new targets for different cannabinoids, which will point out to new treatment options for diseases with unmet needs.


Executive Summary

  • NovoCurmin is a reformulated curcumin complex, protected by 2 international patent applications.
  • NovoCurmin can be used for a diverse array of indications and formulations.
  • The proprietary NovoCurmin complex, only uses GRAS excipients that are approved by all of the major regulatory authorities in the World including the U.S. FDA, EMA, Japan KFDA, and Chinese FDA

Major Advantages

  • NovoCurmin is highly stable
  • Can be used in beverages.
  • Can be used in food products.
  • Can be used in supplements
  • Can be used in Pharma/Trad.Herbal Meds
  • The highest amount of curcumin per mg, that can be loaded compared to competitors.So a significantly smaller capsule size can be used.
  • Significantly lower amount of emulsifier is used per unit dose, so the negative connotation associated with high emulsifier volumes is out of question.
  • NovoCurmin uses a curcumin extract with a DMF(Drug Master File)
  • NovoCurmin can be provided as a ready to fill format in powder or liquid form.
  • Or as a premix for capsules,sachets,food and beverage manufacturing.
  • Or can be provided as a finished dosage formulation according to the client’s specifications.
  • NovoCurmin will be manufactured in a cGMP approved manufacturing facility

Solubility Study Results

NovoCurmin water solubility in comparison with the major solubility enhanced brands in the market.


NovoCurmin Bioavailability in comparison with the major brands in the market.

NovoCurmin has demonstrated  up to 5X maximum plasma concentration compared to well established phytosomal and Y-Cyclodextrin Curcumin Complexes.



Curcumin Global Outlook

  • The global market size is expected to reach USD 1.30 billion by 2024, according to a new study by Grand View Research, Inc.
  • The market is anticipated to register a CAGR of 12.3% until 2024.
  • The market will witness a significant growth in the coming years due to growing consumer awareness regarding the aforementioned therapeutic properties.

https://www.prnewswire.com/news-releases/curcumin-market-size-worth-1-30-billion-by-2025-cagr-12-3-grand-view-research-inc–811278562.html

Current Focus

NovoCurmin, will be one of the few pharmaceutical-grade curcumins with a DMF(Drug Master File) and complete e-CTD dossier, with an opportunity to become a Global product in the nutraceutical, food and beverages market.


Oppurtunity

10 Proven Health Benefits of Curcumin

  • Contains Bioactive Compounds with Powerful Medicinal Properties
  • Natural Anti-Inflammatory Compound
  • Natural anti-oxidant
  • Boosts Brain-Derived Neurotrophic Factor, Linked to Improved Brain Function
  • Lowers Risk of Heart Disease
  • Can Help Prevent (And Perhaps Even Treat) Cancer
  • May be Useful in Preventing & Treating Alzheimer’s Disease
  • Arthritis Patients Respond Very Well to Curcumin
  • Studies Show Incredible Benefits Against Depression
  • May Help Delay Aging and Fight Age-Related Chronic Diseases

Evolution of the Number Of Publications

Related to Curcumin


  1. a) 1871 – 2015
    b) 2000 – 2015
    (source: SciFinder Scholar)

Competition

  • “Curcumin is the most widely-studied plant-derived medicinal chemical in modern science. Based on a statistical analysis of over three million published scientific studies, Curcumin is the most frequently mentioned phytonutrient.“- *NaturalNews.com, July 2013
  • There are 50+ manufacturers selling standard curcumin but most have very poor solubility and corresponding poor Pk(Blood concentration).

Main Enhanced Curcumin competitors:

  • Wacker Chemie – CAVAMAX® W8 Curcumin Complex (Y-cyclodextrin)
  • Indena – Meriva® (Curcumin-phosphatidylcholine phytosome complex)

*http://www.naturalnews.com/041329_curcumin_anti-cancer_scientific_literature.html

Advantages of NovoCurmin

  • The efficacy and enhanced properties of NovoCurmin is proven with numerous in vitro and in vivo studies.
  • Only curcumin product to demonstrate statistically significant advantages vs Top brands.
  • Highest solubilty bioavailability on the market allowing less frequent dosing
  • High curcumin loading capacity enables the formulation to fit into a smaller unit volumes.

Partnering Opportunity

  • DynaSci is seeking a sales and / or distribution partner.
  • DynaSci is interested in global and local partnering opportunities, except for Turkey.
  • NovoCurmin is projected to be commercialized in Q2 2021.

What is Water Soluble CBD?

  • Cannabidiol (CBD) is hydrophobic and mixes well with oil, but not water. Rudimentary knowledge of chemistry reminds us that oil and water do not mix.
  • This is because water and compounds that water dissolves in are hydrophilic (water-loving) while oil and compounds that mix with oil are hydrophobic (water-resistant). Thus hydrophobic molecules can be defined as those that do not mix with water.
  • All cannabinoids do not dissolve in water (i.e, are hydrophobic) and resist absorption into the bloodstream. This is especially true for CBD and THC.
  • This was a thorn in the side of food and beverage formulators who wanted to expand their product portfolio with cannabinoid infused  products.

Why CannabiNext?

  • Over the last year, water-soluble CBD has increased in demand. The ability of a water-soluble CBD allows our customers to create end-products that tailor to savy consumers who consume functional food & beverages products.
  • A water-soluble CBD product is also more efficient due to its increased  bioavailability. This efficiency translates to a more affordable product for the end-consumer, as a smaller dose of the same cannabinoid creates a much larger effect.

      Breadth of possible product formulations

  • Allows unprecedented access into the Functional Beverage Market.
  • Introducing water-soluble cannabinoids in powder form to a diverse array of foods.
  • Can be applied to other cannabinoids such as THC, THCV, CBG, and Cannabitriol among others.

     Customer Preference

  • Consistent and measurable Cannabinoid control.
  • Can be delivered in powder or liquid form.
  • No noticeable impact on flavor, consistency, texture, or appearance.
  • The patent pending complex only uses GRAS excipients that are approved by all of the major regulatory authorities in the World, including the U.S. FDA, EMA, Japan, KFDA, and Chinese FDA.

Major Advantages of CannabiNext Neutron

CannabiNext Neutron CBD formula has demonstrated significant superiority compared with the highest solubility & bioavailability(BA) enhanced products on the market. Our Neutron Technology has a completely neutral taste whilst still preserving the high solubility and BA.

Major Advantages of CannabiNext Neutron

Cannabinext has achieved 32 times higher blood concentration compared with the use of regular CBD, coupled with the advantage of neutral taste.

Major Advantages of CannabiNext Supra

Cannabinext Supra has achieved more than 100 times higher blood concentration compared with the use of regular CBD. This equals to more than 3 times higher blood concentration compared to vaping or smoking.
The product also does not have to be in seml-liquid or oil form to reach this high level of bioavailability and can also be in powder form

Business Model / Growth Strategy